(1:54). Matchup rating: 28.0 | Spread: ATL -2.5 (51), What to watch for: The Cardinals figured out how running the ball can lead to victory. Start in the red zone ... No longer 'Marvin'? Additionally, ESPN Stats & Information provides a stat to know for each game, and the Football Power Index (FPI) goes inside the numbers with a matchup rating (on a scale of 1 to 100) and a game projection. Stat to know: The Jets have started 0-6 only once in franchise history, in 1996. What to know for fantasy: Bucs receiver Chris Godwin has finished three weeks as a top-10 receiver this season, while teammate Mike Evans has finished outside of the top 45 on three occasions. FPI prediction: BAL, 73.5% (by an average of 8.6 points), Matchup must-reads: D is the new MVP: Ravens' D upstaging Jackson ... From QB play to his contract, a look at what's ailing Eagles' Ertz ... Eagles cleared to host limited fans at home games ... "Biggest" Eagles fan sends well-wishes after Prescott's injury, 1 p.m. 2: Packers want second Super Bowl for Aaron Rodgers, Marv Levy, Cornelius Bennett, former Bills eager to see Buffalo 'finally' win title, Who stays and who goes? He caught 11 of 13 targets for 65 yards and a touchdown in his two games against the Steelers last season. Sam Darnold's return from mono will help the Jets out of their offensive funk, but the Cowboys have too many playmakers on both sides of the ball for this to be close. -- Jeff Legwold, Bold prediction: Derrick Henry will rush for more than 100 yards and have two touchdowns. In Week 6, he gets another NFC East rival that has been routinely challenged deep down the field by opponents. But the Falcons will also be trying to avoid their worst six-game start since 2007 (1-5), the season before they drafted Ryan. The Chargers have one of the better pass defenses in the league, but third-string QB Hodges isn't afraid to throw the ball. Matchup rating: 48.5 | Spread: MIN -4 (54.5), What to watch for: What does an 0-5 team look like with a new coaching staff but a season likely past the point of being salvaged? Read more. Jacksonville offensive coordinator Jay Gruden admitted he has abandoned the run way too soon in each of the Jaguars' past two games, so expect him to commit to Robinson pretty heavily against the Lions. It's all here to help get you ready for a loaded weekend of NFL football. FPI prediction: DET, 60.2% (by an average of 3.6 points), Matchup must-reads: What's wrong with Stafford's feet? See Week 6 rankings. The Rams have strong units on … He has rushed for a score in all three of those games, and he even caught a touchdown last weekend at Washington. For Darnold's sake, Jets must rebuild O-line the Dallas way, Mistakes overshadow career days for Cooper, Prescott, Darnold's return intensifies spotlight on Gase, New QB Hodges brings athleticism, 'fearless' approach, Goal-line turnovers an issue for Chargers, Rivers, How Packers' Matt LaFleur is doing what other first-year coaches haven't: win, Against Packers, Lions can lean on Patricia's success against top offenses, Packers' good vibrations: Rodgers likes 'the vibe on this team', Rewriting the Rodgers narrative, according to his backup center, Panthers (3-2) vs. Newton's pick: Panthers 24, Bears 20 His picks are below. • Pack want to help Rodgers get ring No. Week 6 NFL game picks, schedule guide, fantasy football tips and more, Guide to Buccaneers-Packers, Bills-Chiefs: Picks, bold predictions and more, Sources: Lions actively seek to trade Stafford, Source: Chiefs RB Edwards-Helaire likely to play, Sources: Ex-Chargers coach Lynn to be Lions OC, Fins QB coach hire Frye has familiarity with Tua, Williams eyes NFL first: 2 teams in 1 postseason, Texans interview QB McCown, Caldwell for HC job, Finally, Aaron Rodgers vs. Tom Brady: Inside playoff matchup 13 years in making, Why Chiefs' Patrick Mahomes is the premier practitioner of the free play, Matthew Stafford gave Detroit all he had -- on the field and off of it, How Ryan Jensen became the best - and meanest - center in the game, After 13-year playoff drought, Bucs carry hopes of their last NFC championship team, Getting No. What to know for fantasy: Jackson had just one game last season with fewer than 19 fantasy points. The tide has turned in recent weeks, however, as Mixon posted a 6-30-1 line in Week 4 and a 6-35-0 line this past Sunday. Read more. Betting nugget: Miami is 4-0 ATS against the Jets since the start of the 2018 season. He's so quick and explosive, and he can get the ball out of his hand very quickly," Dallas coach Mike McCarthy said. Raanan's pick: Giants 23, Washington 22 But the Cardinals have only three takeaways, tied for the third fewest. Stat to know: The Titans are the only team that has yet to see an offensive drive end in a turnover this season. In their Week 6 matchup, the Chiefs won via the ground game. KC-BUF | ARI-DAL, 1 p.m. Matchup rating: 67.2 | Spread: BAL -7.5 (47.5), What to watch for: Opposing tight ends have racked up 32 catches for 323 yards and five touchdowns through five games against the Eagles, with much of that damage coming against a struggling linebacking corps. -- Jake Trotter, Bold prediction: Chris Carson and Rashaad Penny will combine for at least 150 yards on the ground, which is about what Cleveland's 29th-ranked rush defense is allowing per game. Matchup rating: 14.8 | Spread: DET -3 (55), What to watch for: Look for Jaguars running back James Robinson to carry the ball more than 20 times. Baby's pick: Ravens 35, Bengals 14 In the past 10 seasons, the only quarterback to start his career 5-0 outright and ATS is Patrick Mahomes. Stat to know: The Giants are last in the NFL in rushing, with just 79.0 yards per game. FPI prediction: NO, 57.8% (by an average of 2.7 points), Matchup must-reads: Florida Man 2.0: Behind Minshew's mustache lie 'genius tendencies' ... Can Saints add Fournette to their under-100 club? Watch on ESPN+. What to know for fantasy: In his first season without DeAndre Hopkins, Watson is on pace to set new career highs in both passing touchdowns and passing yards. See Week 6 rankings. -- Mike Reiss, Bold prediction: The Broncos will force two turnovers. And he is 2-0 this season. -- David Newton. Matchup rating: 51.2 | Spread: SEA -1.5 (46), What to watch for: Russell Wilson has been fabulous this season, with 14 total touchdowns and no interceptions. What to know for fantasy: Marvin Jones has scored six touchdowns in five games against the Packers since joining the Lions in 2016. Read more. Quarterback Nick Foles attempted 42 passes in Week 5, but Kmet finished the game with zero targets and played just 21 of 63 offensive snaps. That rate ranks ahead of Brandin Cooks, T.Y. BAL-PHI | CLE-PIT | HOU-TEN Saints 12, Titans 11. One huge stat, Mahomes says ankle injury won't limit his mobility vs. Texans. What to know for fantasy: Minnesota's Cook has had at least 20 touches in every game this season and is on pace for 362. It ranks fifth in sacks with 15, but eight occurred in the opener. FPI prediction: TB, 54.9% (by an average of 1.8 points), Matchup must-reads: Abandoned in London as a child, Efe Obada returns as NFL player ... Bucs to be minus two offensive-line starters ... Addison, Barrett an unlikely pair of sack leaders. Our NFL Nation reporters bring us the keys to every game, a bold prediction for each matchup and final score picks. Stat to know: Matt Ryan has 300 passing yards in every game this season, and he could join Kurt Warner and Steve Young as only players with 300 in each of their teams' first six games in the Super Bowl era (Patrick Mahomes could also do so this weekend). He went 5-0 while at Allen High School, including three state championships, and 1-0 with Oklahoma, winning the Big 12 championship. Gregg Rosenthal went 9-6 on his predictions for Week 5, bringing his season record to 46-31-1.How will he fare in Week 6? FPI prediction: LAC, 64.4% (by an average of 5.1 points), Matchup must-reads: New QB Hodges brings athleticism, 'fearless' approach ... Goal-line turnovers an issue for Chargers, Rivers, Monday, 8:15 p.m. Look for the Smiths (Preston Smith and Za'Darius Smith) to have success against the statuesque Brady, and Kenny Clark's return will help a run defense that so far has allowed nearly 5 yards per carry. What to know for fantasy: DJ Chark was drafted in just 11.8% of fantasy leagues. That has to change. -- Eric D. Williams. -- Mike Triplett. FPI prediction: IND, 67.6% (by an average of 6.3 points), Matchup must-reads: Inability to keep Burrow upright is problem Bengals must fix quickly ... Colts sticking with Rivers at QB despite turnover trouble ... Bengals lose Reader for season with quad injury ... Rivers' turnovers responsible for nine points in Colts' loss, 1 p.m. -- Jordan Raanan, Bold prediction: Washington defensive end Montez Sweat will take advantage of a weak New York offensive line and beat right tackle Cameron Fleming for a sack/fumble that leads to a deciding touchdown for Washington. Since 2015, teams coming off Thursday games are 10-3 ATS against teams coming off Monday games. FPI prediction: BAL, 81.0% (by an average of 12.0 points), Matchup must-reads: How to fix Bengals' struggling offense? Laine's pick: Buccaneers 31, Packers 27 Can the Panthers, who have not allowed a sack in two straight games, keep quarterback Teddy Bridgewater clean against Chicago's Akiem Hicks and Khalil Mack, who have 3.5 sacks each? Cincinnati Bengals at Indianapolis Colts (-8) Sunday, 1 p.m. ET,FOX. No Eagles QB has led the NFL in picks over a full season since the 1970 merger. Let's get into the full Week 6 slate, including a showdown between Tom Brady and Aaron Rodgers. Cleveland (plus 17) at Jacksonville: The Jaguars have only one more game left with a winning team. Why haven't the Cowboys, Prescott agreed on a deal? Jaguars 24, Browns 6. On the flip side, the Rams average 96 yards, and the 49ers' front has been among the best in allowing only 82 per game. -- Tim McManus. Stat to know: Jackson has a 68.4 QBR when pressured this season, the second-best in the league (minimum 20 action plays). Humphrey making big name for himself ... Bengals leaning on strong connections while trying to snap winless start ... From picks to deep passes: Jackson's learning curve still steep, 1 p.m. In their past three games vs. a Gregg Williams-led defense, the Cowboys have averaged 137 yards on the ground and had six rushing touchdowns. And per the Elias Sport Bureau, Green Bay now has four consecutive games scoring at least 30 points with zero turnovers, tied for the second-longest streak in NFL history (2010 Patriots, seven straight). See Week 6 rankings. Matchup rating: 50.3 | Spread: TEN -3.5 (53.5), What to watch for: The Titans will be creative in finding ways to pressure Texans quarterback Deshaun Watson. -- Jake Trotter. Betting nugget: Detroit is 7-1 ATS coming off a bye since the start of the 2012 season. 2: Packers want second Super Bowl for Aaron Rodgers, Marv Levy, Cornelius Bennett, former Bills eager to see Buffalo 'finally' win title, Who stays and who goes? • Full schedule » | Standings » Watson has already been sacked 17 times, third most in the NFL. DiRocco's pick: Jaguars 24, Saints 21 ET | CBS But Washington is second to last at 81.4 rushing yards per game. ET | NBC Betting nugget: Carolina is 3-0 both straight up and ATS in its past three games. -- Jeff Dickerson. 1 receiver: Vikings' Thielen relishing new roles, McCaffrey doesn't have to rush back for Panthers, Panthers' Short to have season-ending shoulder surgery, How COVID-19 put everything on the line for Panthers' Reed, "A student of everything": What a 26-year-old Bill Belichick learned as a Broncos assistant, Broncos coach Fangio forced to take more risks on defense, Inability to keep Burrow upright is problem Bengals must fix quickly, Colts sticking with Rivers at QB despite turnover trouble, Bengals lose Reader for season with quad injury, Rivers' turnovers responsible for nine points in Colts' loss, Jaguars to use fifth kicker of season in Brown, Jaguars among NFL teams using silver to fight COVID-19, Resetting Washington's QB situation: What's next for Allen, Smith and Haskins, Giants' Jones continues to be haunted by last-minute failures, Smith favored to win comeback player award, Giants lose LB Carter for season with ruptured Achilles, How Bell ouster affects Jets' locker room and future cap, Dolphins' Howard, Jones show potential to be top CB duo, Jets to again start Flacco at QB; Gase to still call plays, Source: Dolphins' Godchaux has biceps tear, Bell's ugly ending with Jets raises serious questions, One night in Atlanta 10 years ago, Rodgers became a star, Brady pokes fun at himself while congratulating LeBron, Brady's fourth-down gaffe joins list of other interesting errors with time and turnovers, Rams' Sean McVay remains a football junkie even as he attempts to step back, How Kyle Shanahan has kept the 49ers from falling apart, Rams have a sack party in Washington as they prepare for NFC West, 49ers CB Sherman suffers setback in recovery from calf injury, 49ers QB Garoppolo practices, on track to start, At last, Rodgers vs. Brady in the playoffs, Missing starters evident in Bills' humbling loss on national stage, Source: Hamstring injury could sideline Chiefs WR Watkins a couple of games, Biggest surprises for every AFC team thus far in the 2020 season, Cardinals LB Jones to have season-ending surgery, Even without Prescott, Cowboys say plan stays the same on offense, Hopkins credits Murray, Cardinals' playcalling for hot start, Could Dak still get $100 million? 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